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Confidence Through Testing, Our Clinical Study, Part 1

We embarked on significant testing to prove ClearSynergy is the most effective and gentle acne treatment available.  With our testing completed, we can now state with 100% confidence that we have our proof.

Clinical Study Testing

We ran the gold standard of testing — randomized and double-blind — to compare effectiveness of ClearSynergy® to other leading acne products1.

This independent clinical study was led by a board-certified dermatologist2 and compared ClearSynergy® to the leading benzoyl peroxide, salicylic acid and adapalene acne products at their maximum over-the-counter doses:

  • ClearSynergy® with 0.5% salicylic acid
  • Proactiv+® with 2.5% benzoyl peroxide and 0.5% salicylic acid
  • Neutrogena® RapidClear with 2% salicylic acid
  • Differin® Gel with 0.1% adapalene

The trial period was reduced from the standard 12-week length to a shorter 4-week trial to place the maximum pressure on ClearSynergy® to perform effectively in a shorter time frame.

The data collected during the trial included the percent (%) change for the following measures3:

  • Dermatologist assessment of total lesions
  • Dermatologist assessment of inflammatory acne (papules and pustules)
  • Dermatologist assessment of non-inflammatory acne (close and open comedones)
  • Dermatologist assessment of erythema
  • Dermatologist assessment of dryness
  • Instrument readings from a sebumeter
  • Instrument readings from a moisturemeter

Note: Because the study was randomized and double-blind, the mild to moderate acne prone subjects were randomly assigned to each product, and neither the laboratory technicians, study participants, nor the dermatologist knew which product they used throughout the study and during the assessments and instrument readings.

A statistical analysis was run on the collected data to determine statistical significance (p-value).  This analysis ensured that our conclusions from the data were truly attributed to the acne products we tested, rather than from random skin reactions.

Clinical Study Results

Detailed test results comparing ClearSynergy to the three most popular acne treatments

Clinical Study Conclusions

After reviewing the collected data and analyzing the statistics, the other products had very mixed and unsurprising results:

  • Proactiv+® study participants experienced increased itching, burning, stinging, or irritation along with a significant increase in redness and some dryness but with some help with oily skin. Unfortunately, this product has a well-known tendency to reduce oil too much, which causes problems that users complained about in the study.
  • Neutrogena® RapidClear study participants experienced increased itching, burning, stinging, or irritation along with an increase in redness and dryness but a little help with oily skin.
  • Differin® Gel study participants experienced increased itching, burning, stinging, or irritation along with increased redness but experienced significant improvement with blackheads.

In comparison, ClearSynergy® ‘s results are very clear:

  • Significantly reduced inflammatory acne (red, swollen, and sore pimples)
  • Reduced all types of acne, including blackheads, 100% more than other products
  • Caused zero side effects, including burning, itching, and stinging
  • Reduced redness (erythema) by 21% while the other products increased redness
  • Measurably increased skin hydration while the other products measurably dried skin
  • Reduced oils into the healthy range – not too much and not too little – leaving skin feeling healthy

Read Part 2 of our testing blog to learn about the irritation and sensitization study we also ran.


1 “Skin Moisturization Comparison of Four Over-The-Counter Acne Products” Consumer Product Testing Company Protocol SVGV01-001 May 2019.

2 Current and active board certification by the American Board of Dermatology since 1979.

3 “Healthy sebum levels documented in Endly, D.C. & Miller, R.A. (2017).  Oily skin:  A review of treatment options, Journal of Clinical and Aesthetic Dermatology, 10 (8), p. 49-55.”

Next article Confidence Through Testing, Our HRIPT Testing, Part 2